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Major Adverse Cardiovascular Events (MACE), including Stroke (CVA): Serious heart attack and stroke outcomes

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Moreover, MAPK/ERK signaling upregulates Kruppel-like factor-2 (KLF2) and KLF4, which enhance eNOS expression, inhibit NF-B signaling, and suppress TNF- receptor expression, reinforcing anti-inflammatory and atheroprotective effects [207]

6,409,410 During a previous experiment, researchers induced pain and observed symptoms of cognitive impairment in rats through spinal nerve ligation

6.4.2 Multiple sclerosis Multiple sclerosis is an inflammatory illness that can cause brain and spinal cord damage through inflammation of the central nervous system

Antifade mounting media (Vectashield Cat # H-1000-10) was used, and images were captured by confocal microscopy (Zeiss LSM 880 with Airyscan)